International Journal of Biological & Medical Research EVALUATION OF OXIDATIVE STATUS AND ZINC LEVEL IN LEPROSY PATIENTS AFTER ZINC SUPPLEMENTATION
نویسندگان
چکیده
Leprosy is caused by invasion of Mycobacterium leprae bacilli occurring intracellularly. The innate methods by which the human body meets the challenge of invading live microbes is to destroy the microbes through an activation system leading to biochemical production of oxygen and other free radicals by the phagocytic cells[1] . Reactive Oxygen species (ROS) released during bacterial phagocytosis mediate peroxidation of lipids yielding lipid hydroperoxides (LOOH) that decompose with formed conjugated dienes yielding Malondialdehyde (MDA), which is one of the most widely used markers of the peroxidative process[2]. Oxidative stress ensues when the pro-oxidant antioxidant balance gets perturbed in favour of pro-oxidants.
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